Production on the series began in April 2016 and filming took place in Vancouver and the Moroccan cities of Rabat, Casablanca, and Ouarzazate. A pilot was ordered in August 2015 and the series was greenlit in January 2016. New cast additions include Mark Feuerstein, Inbar Lavi, Augustus Prew, Marina Benedict, Rick Yune and Steve Mouzakis. Wentworth Miller and Dominic Purcell reprise their respective roles as Michael Scofield and Lincoln Burrows, while Sarah Wayne Callies, Amaury Nolasco, Paul Adelstein, Robert Knepper and Rockmond Dunbar also return from the original series. The season premiered on April 4, 2017, and concluded on May 30, 2017, consisting of 9 episodes. Moritz and Dawn Olmstead, Vaun Wilmott, Michael Horowitz and Nelson McCormick serving as executive producers.

Paul Scheuring serves as showrunner, with himself, Marty Adelstein, Neal H. The season is produced by 20th Century Fox Television in association with Adelstein Productions, Dawn Olmstead Productions, One Light Road Productions and Original Film. The fifth season of Prison Break (also known as Prison Break: Resurrection ) is a limited event television series and a revival of the original series created by Paul Scheuring that aired on Fox from 2005 to 2009.